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Brain Development
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Brain Development: Normal Processes and the Effects of Alcohol and Nicotine

Michael W. Miller

Abstract

This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic ... More

Keywords: nervous system, genetic factors, epigenetic factors, mental retardation, prenatal alcohol exposure, nicotine, neurotransmitter systems, ontogenetic processes, neural networks, dysfunctional brain

Bibliographic Information

Print publication date: 2006 Print ISBN-13: 9780195183139
Published to Oxford Scholarship Online: January 2010 DOI:10.1093/acprof:oso/9780195183139.001.0001

Authors

Affiliations are at time of print publication.

Michael W. Miller, editor
Department of Neuroscience & Physiology, SUNY-Upstate Medical University, Syracuse

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Contents

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Part I Normal Development

2 Cell Proliferation

Bernhard Suter, and Pradeep G. Bhide

4 Neuronal Differentiation: From Axons to Synapses

C. David Mintz, Iddil H. Bekirov, Tonya R. Anderson, and Deanna L. Benson

5 Cell Death

Stevens K. Rehen, and Jerold J.M. Chun

6 Intracellular Pathways of Neuronal Death

Sandra M. Mooney, and George I. Henderson

7 Developmental Disorders and Evolutionary Expectations: Mechanisms of Resilience

Barbara L. Finlay, Jeremy C. Yost, and Desmond T. Cheung

Part II Ethanol-Affected Development

9 Influence of Alcohol on Structure of the Developing Human Brain

Susanna L. Fryer, Christie L. McGee, Andrea D. Spadoni, and Edward P. Riley

13 Mechanisms of Ethanol-Induced Alterations in Neuronal Migration

Julie A. Siegenthaler, and Michael W. Miller

15 Neuronal Survival is Compromised by Ethanol: Extracellular Mediators

Michael W. Miller, Maria B. Bruns, and Paula L. Hoffman

16 Intracellular Events in Ethanol-induced Neuronal Death

Sandra M. Mooney, Michael W. Miller, and George I. Henderson

17 Neural Crest and Developmental Exposure to Ethanol

Susan M. Smith, and Katherine A. Debelak-Kragtorp

18 Glial Targets of Developmental Exposure to Ethanol

Consuelo Guerri, Gemma Rubert, and Maria Pascual

Part III Nicotine-Affected Development

19 Tobacco Use During Pregnancy: Epidemiology and Effects on Offspring

Jennifer A. Willford, Nancy L. Day, and Marie D. Cornelius

20 Prenatal Nicotine Exposure and Animal Behavior

Brenda M. Elliott, and Neil E. Grunberg

22 Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders

Kurt F. Hauser, Nazira El-Hage, Shreya Buch, Gregory N. Barnes, Henrietta S. Bada, and James R. Pauly

23 Nicotinic Receptor Regulation of Developing Catecholamine Systems

Frances M. Leslie, Layla Azam, Kathy Gallardo, Kathryn O’Leary, Ryan Franke, and Shahrdad Lotfipour

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