Mechanics of tumor growth: Multiphase models, adhesion, and evolving configurations
This chapter provides the basics to deduce multiphase models for the essential constituents present in tumours (cells, extracellular matrix, extracellular liquid, and possibly blood and limphatic vasculature). All the steps of the modelling procedure are explained in detail, special attention being paid to the meaning of all the different terms involved in the model. The chapter focuses on several mechanical aspects related to tumour growth, e.g., the activation of mechanotransduction pathways inside the cell, contact inhibition phenomena, the formation of stiffer fibrotic tissues, the adhesion phenomena characterizing the mechanical interaction between cells and between cell and extracellular matrix, and cell re-organization within the tissue.
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