Gene Pleiotropy and Evolution of Protein Sequence
The concept of gene pleiotropy may play a key role in developing an integrated view of protein evolution. Although the capacity of a gene that may affect multiple phenotypic characters has been used to explain many biological phenomena, little has been known about the extent of pleiotropy at the genome level. Based on the premise that links between gene pleiotropy and the dimensionality of organismal fitness, the author of this book has provided a feasible statistical framework to estimate the degree of gene pleiotropy. This chapter discusses this issue.
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