The aging genome
The emergence on the stage of DNA damage immediately raises the question of whether this type of genome alteration can itself be a cause of aging, or its molecular consequences in the form of mutations; that is, changes in DNA-sequence content. In addition, the recent realization that epigenomic modifications should also be considered as genuine changes in the genetic code introduces yet another potentially pro-aging type of genome alteration. Like DNA-sequence alterations, epigenomic changes are now considered as causes of cancer. This chapter considers the types of genome alteration that occur spontaneously in organisms, and their frequencies in aging cells and tissues.
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