Neuroimaging in Levodopa-Induced Dyskinesia
The pathophysiology of levodopa-induced dyskinesias (LID) is complex and cannot be explained by a single factor. PET imaging has provided novel insights into the understanding of this common side effect of dopaminergic therapy. In this chapter, functional imaging studies of LID are reviewed with a detailed summary of investigations of the relationship between LID and abnormalities in dopaminergic functioning, as well as changes in other neurochemical pathways. Recent studies linking LID to chronic changes in vascular microstructure and alterations in the normal neuro-vascular couple are also discussed.
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