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Imaging in Parkinson’s Disease$
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David Eidelberg

Print publication date: 2011

Print ISBN-13: 9780195393484

Published to Oxford Scholarship Online: September 2011

DOI: 10.1093/acprof:oso/9780195393484.001.0001

Parkinsonian Tremor

Chapter:
(p.64) 6 Parkinsonian Tremor
Source:
Imaging in Parkinson’s Disease
Author(s):

Ioannis U. Isaias

Angelo Antonini

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195393484.003.0046

Parkinson’s disease (PD) tremor has been found to be a variable clinical feature of the disease both across patients and within individual patients over the disease course. Clinical ratings of tremor severity have been found to have limited utility as objective measures of this poorly understood disease manifestation. Recent advances in functional neuroimaging methods have, however, provided new insights into the pathophysiology of PD tremor. This chapter reviews concepts of tremor pathogenesis in PD in light of recent imaging studies and discuss the use of imaging methods to differentiate tremor due to PD from essential tremor (ET). The chapter also provides an in depth discussion of the potential utility of image-based tremor biomarkers in delineating the natural history of PD tremor and in the objective assessment of its response to specific therapeutic interventions such as deep brain stimulation (DBS).

Keywords:   PD tremor, neuroimaging, essential tremor, natural history, treatment effects, deep brain stimulation

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