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Cancer Epidemiology and Prevention$
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David Schottenfeld and Joseph F. Fraumeni

Print publication date: 2006

Print ISBN-13: 9780195149616

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780195149616.001.0001

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ContentsFRONT MATTER

Biliary Tract Cancer

Chapter:
(p.787) 40 Biliary Tract Cancer
Source:
Cancer Epidemiology and Prevention
Author(s):

ANN W. HSING

ASIF RASHID

SUSAN S. DEVESA

JOSEPH F. FRAUMENI

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780195149616.003.0040

This chapter reviews the epidemiology of biliary tract cancer. Many etiologic leads for biliary tract cancer have come from clinical observations, autopsy series, and descriptive epidemiologic studies. While a significant fraction of these tumors are related to gallstones (cholelithiasis), information on other risk factors is limited, due to the rarity of the tumors, the often rapidly fatal course, and the small number of epidemiologic studies conducted to date. Because the three anatomic categories of biliary tract cancer have distinct epidemiologic patterns and molecular changes, including somatic mutations and loss of heterozygosity (LOH), it has been suggested that the causal factors vary by subsite.

Keywords:   biliary tract, cancer risk, cancer epidemiology, cancer prevention, gallstones, cholelithiasis

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