Public health assessment of genetic susceptibility to infectious diseases: malaria, tuberculosis, and HIV
The understanding of the host genetic factors that influence susceptibility to and the course of infectious diseases is growing rapidly. Even for the most common pathogens, however, there is an incomplete understanding of all the important genes. As sequencing of the more than 100,000 human genes continues and as technologies advance, new discoveries about host genes and their role in infectious diseases are made almost daily. Translating this knowledge into public health actions, particularly those aimed at combating and controlling infectious diseases, is a major challenge. This chapter focuses on this downstream phase of genetics, particularly on how new knowledge can be integrated into existing public health programs and strategies.
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