Voltage-clamp studies in axons: Macroscopic and single-channel currents
This chapter describes macroscopic membrane currents measured in amphibian and mammalian nodes of Ranvier with the voltage-clamp method. These results are compared with those of single-channel recordings, which provide important data on channel characteristics in myelinated axons. The results obtained from the calculation of the action potentials with voltage-clamp data obtained from frog, rat, and human nerve fibers are also reviewed. It is shown that the properties of the various new ionic channel types detected with the patch-clamp technique help explain previously unsolved problems concerning the ionic basis of accommodation, resting potential, and various pathophysiological phenomena.
Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.
If you think you should have access to this title, please contact your librarian.