5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology
The fact that antagonists at certain 5-HT receptor subtypes are effective in the prophylaxis or treatment of migraine implicates the endogenous amine in a causal role in the condition. On the basis of the properties and selectivities of such antagonists, this chapter discusses the potential significance of 5-HTlc, 5-HT2, and 5-HT3 receptors in the initiation, development, and symptomatology of migraine. The likely source(s) of the 5-HT needed to stimulate these sites are considered, and a hypothesis is proposed to implicate the activity of the 5-HT neurones arising in the mid-brain raphe nuclei in a key role in the aetiology of migraine. The ideas discussed here are developments and extensions of those expressed over a number of years in several review articles and are by no means unique.
Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.
If you think you should have access to this title, please contact your librarian.