From genome to phenome
This chapter discusses a possible causal relationship between stochastic accumulation of genome alterations and the aging phenome. Genome alterations are those changes that irreversibly alter the information content of the genome. This includes chemical changes in DNA primary structure, alterations in DNA sequence or DNA sequence organization, as well as epigenomic alterations, such as changes in methylation patterns or histone modification. For the purpose of this discussion, it is necessary to define the aging process, not on the basis of the demonstrated mortality increase in aging cohorts, but as a series of degenerative processes occurring in individual organisms over their lifetime.
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