Dopaminergic Imaging in Parkinson’s Disease: PET
Positron emission tomography (PET) is a functional imaging technique utilized in Parkinson’s disease (PD) largely to assess the integrity of the nigrostriatal dopamine system. This chapter reviews the methodological aspects of dopaminergic PET imaging particularly involving specific radiotracer approaches to quantify pre- and postsynaptic function in health and disease. Also discussed are applications of dopaminergic PET for differential diagnosis, evaluation of non-motor disease manifestations, and the objective measurement of disease progression in clinical and genetic disease subtypes. The potential limitations of this imaging approach are also addressed.
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