Oxford Scholarship Online: Macromolecular Crystallography

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Subject: Biology Book Title: Macromolecular Crystallography

Macromolecular Crystallography conventional and high-throughput methods Sanderson, Mark R. (Editor), Randall Division of Cell and Molecular Biophysics, King's College London, UK. Skelly, Jane V. (Editor), Medway School of Science, University of Greenwich, UK. Print publication date: 2007 Published to Oxford Scholarship Online: September 2007 Print ISBN-13: 978-0-19-852097-9 doi:10.1093/acprof:oso/9780198520979.001.0001
Abstract: Abstracts and keywords to be supplied. Table of Contents Full Book Contents Preface CHAPTER 1. Classical cloning, expression, and purification CHAPTER 2. High-throughput cloning, expression, and purification CHAPTER 3. Automation of non-conventional crystallization techniques for screening and optimization CHAPTER 4. First analysis of macromolecular crystals CHAPTER 5. In-house macromolecular data collection CHAPTER 6. Solving the phase problem using isomorphous replacement CHAPTER 7. Molecular replacement techniques for high-throughput structure determination CHAPTER 8. MAD phasing CHAPTER 9. Application of direct methods to macromolecular structure solution CHAPTER 10. Phase refinement through density modification CHAPTER 11. Getting a macromolecular model: model building, refinement, and validation CHAPTER 12. High-throughput crystallographic data collection at synchrotrons CHAPTER 13. Electron density fitting and structure validation CHAPTER 14. RNA crystallogenesis CHAPTER 15. Crystallography in the study of protein–DNA interaction CHAPTER 16. Virus crystallography CHAPTER 17. Macromolecular crystallography in drug design Index

doi:10.1093/acprof:oso/9780198520979.001.0001