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Subject: Biology  Book Title: Darwinian Detectives
Darwinian Detectives
Revealing the Natural History of Genes and Genomes
Johnson, Norman A. Adjunct Assistant Research Professor, University of Massachusetts, Amherst
Print publication date: 2007
Published to Oxford Scholarship Online: September 2007
Print ISBN-13: 978-0-19-530675-0
doi:10.1093/acprof:oso/9780195306750.001.0001
 
Abstract: Some six million years ago, two branches of the evolutionary tree diverged: one that led to chimpanzees and bonobos, and one that led to us. Extraordinary advances in our ability to obtain and process DNA sequence information permits scientists to address fundamental questions about the evolutionary histories of varied species, including our own. Ascertaining the sequence of the genome — the complete complement of DNA information — from both humans and chimpanzees allows scientists to address such questions as: which genes were subjected to natural selection along our evolutionary branch? Are these the genetic changes that made us human? The book addresses these and other questions about human evolutionary history, including our domestication of other animals and of plants. It also explores how researchers use the tools of molecular genetics and population genetics theory to unravel the secrets of the natural histories of genes and genomes. Much like detectives looking to ascertain the circumstances behind a crime, these scientists can develop and test inferences about the nature of the natural selection and other evolutionary pressures that have shaped the organisms that harbor these genes.

Keywords: chimpanzees, DNA, domestication, evolution, genes, genome, humans, natural history, natural selection, population genetics
Table of Contents
Preface
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1. The Baby with the Baboon Heart
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2. Why Intelligent Design Is Not Science
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3. Negative Selection and the Neutral Theory of Molecular Evolution
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4. Detecting Positive Selection
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5. Balancing Selection and Disease
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6. Finding Our Roots
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7. Who Were the Neanderthals?
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8. Are We the Third Chimpanzee?
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9. What Are the Genetic Differences That Made Us Human?
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10. Clicks, Genes, and Languages
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11. Who Let the Dogs in?
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12. Size Matters
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Bibliography
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Index
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doi:10.1093/acprof:oso/9780195306750.001.0001
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